The fact that heat is evolved when ... is of great practical consequence (or importance).
These results hold much biological significance.
The design of the casting is of major importance.
Of importance in the study of ... is the triple vector product.
The convergent-divergent nozzle is critical to the optimum performance of ...
Nitrogen purity is of prime (or paramount, or great) importance.
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be of great importance, be essential
be important, be significant